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Washed Up Pharmacist's avatar

Hi Sylvia

Regarding SO1, Pfizer actually PUBLISHED some of these results in a peer reviewed journal.

see here. https://jpharmsci.org/article/S0022-3549(23)00009-6/fulltext

However, some of the information in the release is NOT included in the article by Patel, specifically Figure 9. Also note a few admissions from these Pfizer scientists in the second last paragraph.

1. a hidden gene (which Kevin McKernan and others have found)

2. poly (A) tail design ie the segmented poly A tail which may be translated....

For the release for SO1 November 2021, note BioNTech used an engineering run for the analysis. This engineering run, 1071509, is I believe, manufactured in March 2020 and is a Process 1 batch. As a result, the 5' cap and poly A tail quality and quantity will be much different. I also believe the residual DNA in this batch is very high but the dsRNA is very low based on data on the leaked Rolling Review.

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Monica's avatar

Oligonucleotide Mapping via LC-UV-MS/MS to Enable Comprehensive Primary Structure Characterization of mRNA Drug Substance (by Pfizer) PDF

https://mamconsortium.org/wp-content/uploads/2023/10/2023Sep28_MAMConsortium_OligoMapping_GAUB.pdf

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